I'll put in my two cents here.
As a Colt/S&W pistol smith myself, I own and shoot all of my revolvers. I have three Pythons, two Anacondas, two Colt 3-5-7's, a MK III, a MK V, and a number of older colts in 38 special. For S&W I have 686, 66, 19, model of 1989 N frame, and many more... also a Dan Wesson collection in 357 mag and 44 mag. I have not personally purchased any Rugers. I have shot some nicely tuned GP100's but the ones I tried out of the box were not inspiring.
The Python actions do have a weakness when a lot of full house 357 rounds are fired. I've worked on a few of them where the timing was slightly out from wear and tear. The Pythons that did exhibit this timing issue were typically found in guns that have seen a lot of rounds, and I mean like 20 years of being daily shooters and being used for competitions. The repair is not difficult and the hand that is required is readily available as it's a common wear item for Pythons. I get my Colt parts from canadabrass but there available from the US as well. If a Python is in great shape it'll run for many many years without issue unless it gets abused in some way.
I have a new Python that is now my daily shooter and has displaced my 686. The new Pythons don't feel as good as the older ones but can be tuned to amazing levels if you know a smith. The new Pythons are simpler actions and made with harder steel which should not have the same problem the older ones may display after years of use. For the record, my 686 also went out of time and I had to replace the ratchet on the cylinder. If you know how to check revolver timing correctly you may find your S&W is out too! There are S&W's out there that are out of time, if only ever so slightly and only when really dirty but many don't know it.
The Dan Wessons are the best kept secret in my opinion. You get an amazing revolver at a currently undervalued used price. They can also be tuned up to competition level triggers.
Long story long, If I was the OP and wanted something to shoot like crazy, feel decent without a pistol smith required to tune it first, and pass on to family when I'm gone, it would be a new Python. There's other great options depending on what you can find used, like here on CGN you could run into a tuned DW 15 or 715, GP100, S&W model 66 or 686 and get a great life long friend. It will hold it's value but it won't as well as the colt. That colt action is a different shooting experience to the others and I personally prefer it.
The suggestions for MR73 or Korth are valid too if your in that price range. Cannot fault either of those out of the box accept for the investment to get one.