I have used the 120 gr TTSX bullets on deer in a 7x64 rifle which is merely a metric 280. It kills very effectively. Maybe not the best bullet for larger game but it is great on deer
120 TTSX works good, even on moose. Here's one that didn't go anywhere with a 300 yard shot from a 7-08 (2950 fps muzzle, approx impact speed 2250 fps, about what a 280AI would deliver @ 450 yards)

Putting together a 280ai based off a sako AV action. going with a 24" gain twist barrel. Plan to shoot 160 gr partitions out of it. Still debating to go with either H4831sc,H4350 or Viht N560.
N560 will give a bit more velocity that H4831sc. Both would be worth a try