There have been a few comments that I am interested in responding to. Lets begin with discomfort from the noise of the report. On the range, everyone should be wearing hearing protection, but for those of us with ATC,s sometimes a shot might be fired without having time to take the proper precautions. When shot without hearing protection, and when being shot from guns with equal length barrels, I find a .357 magnum far more unpleasant than either a .44 or .45 caliber revolver.
As for which cartridge is most accurate, it comes down to the quality of the individual guns. The gun whose chamber throat most closely matches the diameter of the bullet will generally produce the best accuracy providing other aspects of the guns are equal; barrel uniformity, timing, etc. On the target range, the bigger the bore, the greater the scoring advantage as usually a cut scoring ring makes the higher score, so with equal placement a .45 might cut the ring that a .38 will not.
In defensive shooting against beast or man, the bullet with the largest frontal area combined with the greatest momentum will create the largest wound cavity. Again this gives the edge to the largest caliber, if we accept that the practical limits to handgun velocity do not result in dependable bullet expansion.