Some guy in the U.S. makes "short lifters" for the Henry 1860's and the 1866 and 1873 rifles so you can run the Colt Cowboy cases. When you think about it, if you had say an 1866 Carbine and got that short lifter, the Colt Cowboy loaded with around a 214 grain RNFP bullet would give about as close a modern performance to the original .44 Henry rimfire round as you're likely to get. You'd also get original mag-tube capacity. It would not surprise me a bit if that 23 grain load/225 grain Lyman load I make for my wife would be near-bang-on to original Henry .44 RF performance out of one of those rifles.
Bullet diameter on the .44 Henry was .446, so that's closer in fact to a .452 .45 bullet than it is a .429-.430 .44 bullet. If somebody gifted me a .45 Colt 1866, I'd sure think about going down that road. Hell, I have thought about it. Get rid of Trudy and make Canada a shootin' country again and I might. Or maybe, that would have to be a Mexican project.
A .45 Colt 255 grain loading beside the 225 grain Lyman bullet 452374 loaded into a 45 Cowboy case. And a beat-up 9mm dummy-round for size comparison. That Lyman 225 grain bullet -- originally meant for the .45 Auto -- is great for the Cowboy case because it only has to be down in the case about .25 of an inch or less to crimp above the lube groove. That's how you still can comfortably get 23.0 grains into the case. If you really lean on the powder compression die, you can get 25.00 grains in but it doesn't seem to help any.
I pack my wife's Cowboy reloads in a vintage Schofield Box I got from Buffalo Arms when I bought the powder compression die. She loves her guady Pietta Peacemaker, and the Cowboy load in either Black Powder or Smokeless is a lot easier on her than the full 45 Colt loading for sure.