This discussion is interesting, but the more we learn, the more we know that we do not know - it is much like raising kids - confidence gives way to honesty.
Not knowing that 22 250 was too small for deer, we used it for 25 years, bringing up kids with no flinch, no scope-skidding and accuracy and range far beyond 200 yards - we have a 400 yard range, but zero at 200 - and shoot lots to build confidence in everything and everyone.
I've loaded and shot deer with everything from 35 grain V max at 4200 fps - hollowpoints at 4000, 52, 55 sp at just a little slower, and yesterday, a daughter took one with a 55 gr Nosler Armageddon (a very thin jacket and a little plastic point, meant to blow up in a gopher.) He was angling downhill towards her at 70 yards and the shot went just above shoulder blade, angling down towards lungs - it shattered tops of ribs, and so dislodged the spine, and it expired immediately. I am a believer in the ability of a very fast expanding bullet for deer.
We have talked about deep penetration, and long wound channels and bullet weight retention etc. forever, and so the ammo manufacturers give us what we talk about, but I'm not sure that a solid copper projectile is the best for any but just a few situations - if it expands optimally at 100 yards, how well does it expand at 350 yards? - and when there is an exit hole, that is nice to trail, but a smaller, faster bullet that dumps all of the energy and actually drops the animal might be better?
I'd love to ramble on about how little I am sure of anymore - but right now, I am certain that there is a deer to cut.