I remember shooting at a coyote with those in the early 1990's.... I had a model 70 featherweight 30-06 at the time. It was sighted in with 165 grain Federal ammo, but not knowing any better at the time, I thought the 110 grain bullet would be better for a coyote. Of course I missed three times. The point of impact was so far off I couldn't have hit a 12 inch target at 100 meters.
A total rookie mistake, ( was young and didn't know any better at the time ), and learned a good lesson. I hope your nephew re zero's his rifle with those before he shoots at any animal.