I think most inlines ML can be shot at 200 yards. I have shot deer at 200 + when using loads of 100gr of T7 FFG(approx equiv of 115gr BP). Its more about finding the best combo then putting in the approriate range time to be proficent with it. Not only MV at work the low BC of the projectiles used in a 50 cal ML making them more suspect to drift, etc. Certainly doable though provided you'll shoot it in practice and realize that under certain conditions making the long shots just isn't practical.
As far as the savage and safety, it just maybe the safest production ML on the market it will stand pressures far in excess of the reccomended loads. The savage is an animal though, it can do some amazing things but is quirky as well. Not a first time ML IMHO.
I find it funny that people can suggest traditions and cva's without mentioning safety as neither of these companies proof rate their barrels but suggest you can use magnum charges...which I think is very unsafe. I have nothing against either brand but wouldn't go dumping 150 grains of powder in them. 120 Pyrodex or equiv would be the max, I'd stop at 110 T7 FFG or FFFG just to be safe.
I weigh my BP and sub loads as well b/c the variances between volume pours. I take an average weight based on volume pours and then duplicate it. My groups have shrinked slightly but my group average is much better as my flyers are way down. So weighing for the savage is natural.
Yes i own both sub shooting inlines and savage 10 II's. Both have advantages both have disadvantages, both have killed deer past 200 yards. In honesty i like playing with the savage but like blowing smoke more. I find myself now looking for a new sub shooter, as after 1500+ rounds through the savages I am to the point where it's not new anymore and find the need to start over. I admit it's an addiction, hunting has become the bonus...lol!