My original question was for people who had actual experience with. 22 ceterfire on big game.
I have. My kids have. A couple of gf's, and some buddies have with my rifles - 223's and 223AI's, and just working on finalizing an 88 ELD m load in a new 22 Creedmoor that has yet to put any bullets into animals. I fell into the 22 centerfire rabbit hole better than 17 years ago now.
Off the top of my head I've used or first hand seen used mono's - 45/50/53gr TSX, 62gr TTSX, 50gr GMX.
I've also used/seen used the 75gr Amax, 75gr HPBT, 77 TMK, and 88 ELD m, as well as the 40gr vmax, now that I think about it.
I've used rifles twisted in 1:7/8/9/12, with muzzle velocities from 3850 fps down to 2650 fps. Twist rates make a difference in bullet behavior when it hits meat. As does bullet shape and construction.
I've used (or seen used first hand) all the bullets mentioned above on game, from coyotes/whitetails/muleys/black bears/elk/and moose. I have not seen each bullet used on each species (the exception being that I have killed coyotes with all bullets mentioned.)
I've stuck/seen stuck all of the mono's listed into whitetails, and muleys from 91 yards through to 277 yards. The 45 TSX at 3500-ish impact velocity was the most decisive of the mono's - likely due to impact velocity, but the 50 GMX also bang flopped a big whitetail for my daughter, but she shot him in the throat patch and demolished his spine so that wasn't surprising.
Additional to THAT, I've stuck the 75 Amax and 88 ELD m as well as the 53 TSX and 62 TTSX into black bears, from 2 yards out to 486 yards.
With whitetails and muley's, I've shot/seen shot the 75 Amax/HPBT, 77 TMK, and 88 ELD m from 51 yards to 494 yards.
I've killed 3 bull moose in three years with the 88 ELD m, as well as a bull elk. 109 yards on the elk, 151/176/352 yards on the mooses.
The 88 ELD m and 77 TMK aren't even a part of the same discussion when it comes to killing stuff, as the rest of the bullets mentioned. The 75 Amax is a murderous bullet, but the 88 ELD m and 77 TMK are prolific serial killers and there is no end in sight.
Fast twist rates coupled with long, heavy for caliber bullets kill way outside of what a person would expect, and truly has to be seen first hand to understand. Twist rates matter, bullet shape and bullet construction matter. In a larger caliber rifle it is tough to pick the wrong bullet and not get the results that Joe Average wants, in a small caliber rifle it is much easier to get it wrong.
I switched from using 150gr TTSX's from a favorite 280AI as my primary moose rifle to the 88 ELD m in a matching rifle purely because I was getting more damage to organs from the 88, and stuff was dying faster and covering less ground. In fact after using the first one, I have had 3 more rifles built specifically around the 88 ELD m for myself and a buddy, and all are primarily used as killing rifles.
I still use the same bullet placement with the 88's as I was with the TSX/TTSX from my 280AI, 7wsm, or 300 Ultra. I'm still breaking shoulders. Only differences are that now I'm not getting a bullet channel through the ham and finding a bullet under the hide on the back leg on hard quartering in shots like was common with the 300 Ultra and TSX's, and stuff isn't still breathing when I walk up to it after it had an 88 ELD m or 77 TMK stuck in the front half - like was common with anything shot with a Barnes mono.
None of the animals shot with the mouse rifle have made it out of sight since I switched over to the 88/77. There is no guessing on where the bullet landed after the trigger was squeezed because now I see the fur ripple when the bullet lands.
And I realize that this is likely to torque a lot of folks up to read, so by all means use what makes you happiest and fills you with the most confidence when you are hunting. I know I do.
Bullets matter, and picking the right ones always helps, no matter what you are planning on sticking them into.
. 
RJ
