I've shot moose, elk, deer, bears, coyotes and rabbits with a 257 Rob as well as a 25-06.
One year in particular was great for comparison by the way. I shot a moose with the 257Rob and an elk with the 25-06. There wasn't any difference noticed in killing effectiveness between the two.
Both were loaded with 115 grain bullets for all game taken. Up to 300 meters there was little if any difference in hold and all bullets performed very well.
The bullets fired from the Rob and the 25-06 were very seldom recovered, they usually passed all the way through. The moose mentioned above was hit in the lung area, went through a rib on entry and exited a rib on th opposite side, comeing to rest in the hide. The shot was straight on and on level ground.
In the case of elk above, the bullet wasn't recovered, but there was an exit wound about 3cm in diameter where the bullet passed through the shoulder blade. The shot was taken on an uphill angle and at a 30 degree angle from about 200m.
I've never recovered a bullet from bears, deer or anything else.
A friend, now deceased, loved the 257 Rob and used it for all of his serious hunting, which was incredibly extensive and far reaching.
He used a Shilen barrel on a model 700 short action and a model 7 with a Shilen barrel as well. Now here is the real hitch, he was tall and long necked and as many fellows with his body shape, was recoil shy. Both of his 257 Robs had 1/14 twist rates and wouldn't stabilise anything heavier than 100gr flat based bullets. Didn't slow him down one bit though and he would often regale people with a "Pink Mountain" story, where all of the rifles on the hunt were out of service for several reasons (mostly the cold weather) and how his 257 Rob took all 6 moose shot on the trip.
If your bullets are good and you do your part with a suitably accurate 257 Rob, there won't be any problems on your hunt.
I've seen deer and bears shot through the front shoulder with the 257 Rob and will admit, there was a lot of bruiseing and blood shot meat. That is where larger diameter, heavy bullets shine. Especially the 338 and larger. They just don't seem to damage as much meat. Mind you, if you hit any animal in the shoulder, with any bullet, there is going to be meat damage.
bearhunter