Both powders have produced great results for me in the 308 Winchester case. Both produced great accuracy, but R15 will get you less pressure and higher velocity (by sometimes as much as 100 FPS), so I really consider it the best of the two (that said, Varget is such a close second, and cheaper to boot, that I shoot Varget almost exclusively these days).
Varget is the only one of the two I've chronographed out of the same gun in both cold and hot weather (-15 to +30). I don't have the exact numbers handy, but I recall that it lost about 80FPS between the temperature extremes -- which was more than I was expecting, given Hodgdon's advertising it as a temp-insensitive powder, but still so small as to make little practical difference in a hunting rifle.
Other side note - those 168 Nosler BT's worked awesome for my wife last year. She shot two deer (one of them a big mature mule deer), both at sub-100 yard range - both of them reacted like they were hit with a truck, and were dead and down within 2 to 3 seconds. I suspect that they'd bet a bit soft of a bullet for an uber-magnum, but in the 308, they are downright awesome on-game performers! My load is 44 grains of Varget, neck sized brass, and CCI primers - gets me about 2720FPS and very nice accuracy.
One other thing worth noting - 150 grain Nosler AccuBond's have shot more accurately than the 168's in both of the 308's in which I tried both bullets. The AccuBond is also a spectacular performer on-game.