Are you asking about shooting animals at that range or just target shooting?I'm assuming you mean hunting...wow,that's getting out there for a roundball in any caliber but the .54 would be my choice if you're well practiced and know it's trajectory.That's too far imho for a .50rb on deer size game,maybe ok with a .50 conical but again only if you know the rainbow trajectory extremely well.For the most part,esp. with PRBs,expect to keep your shots within 100 yards.I see you've linked to the ML forum,there's a wealth of info to be found on those pages,hardcore traditionalists only,in-line zipgunners need not apply for membership,LOL.