To the OP, there is no doubt that the tsx (and x bullet predecessor) has been one of the most successful, and controversial, bullet introductions .... well, ever.
They are a well designed, good performing bullet. However, they are expensive. They will run you over $1 each. If you are willing to spend the money and shoot a lot, then they are an excellent choice. However, if you are a "I only shoot 3 shots a year; 2 to sight in and 1 for my *deer/elk/moose/etc.*" then I guess they are also a good idea, as you will likely need the penetration performance of the tsx sooner or later. If you are getting into reloading to save money AND shoot more, then there are many other good choices out there that will also perform admirably on game and not break the bank in a days shooting.
Seriously, I shoot a lot less then many people I know, and I still manage to shoot through a few hundred rounds out of my hunting rifles in a year. FWIW, I am not willing to spend $1.25+ per round for practice, and I only practice with my hunting rounds. Do not believe for 1 second that you need the "premium" bullets to kill a deer (or whatever). The tsx is great for those who are willing to pay for it, and is an excellent choice for a number of hunting applications (big bears, hyper-velocity cartridges and close range shots) but they are not necessary.