I've done a lot of pretty stupid things with guns and reloading over the decades, I've fired loads that actually welded (soldered?) the case head on to the bolt face, I've got direct experience with the gas-handling from failed cases in a Springfield 1903, Mauser '98 and Remington 700 LA, (all of them worked as designed), I've bulged the cylinder on a .357 and I've "opened-up" the choke on a shotgun.
And I will tell you this... actually "blowing-up" a gun from badly reloaded ammo isn't a matter of a small error or two, it's only something way wrong that will cause a modern, well maintained firearm to Ka-Boom on you.
Never have more than one type of powder open on your bench at any one time, really.
Wrong powder type and obstructed barrel are really the only common cause of catastrophic rifle failures (if you don't count manufacturing defects, which we really have no control over).