I'll do a couple groups at 25 yds to get on paper and save ammo, then move out to 100...even if I've first bore-sighted the rifle.
1" at 25 yds equals 4" at 100, and 8" at 200. So one does not have to be very much off of dead center at 25 yds to see groups land 4" to 8" off of center at 100 to 200 yds. And what appears to be a wonderfully tight cloverleaf group at 25 yds can turn into a 2" to 4" group at 100.
I wouldn't pay much attention to this seemingly big difference between the two ranges. Once generally on center at 25 yds, move out to 100 yds and begin the real process of sight in there.
One thing to note, just in passing, no idea if this applies or not...
If using rear windage adjustable dovetail rings and bases, moving the rear rings east/west to save on internal adjustments of the scope, while a good idea, is almost certainly going to cause torquing of the scope tube, which, if severe enough, can mess up internal workings, or even actually put a permanent bend in the scope that can only be repaired by the factory. The front rings are far too tightly twisted and locked into the front base to compensate. This is precisely why I only use Burris Signature rings, as I can loosen the front rings a tad and allow the scope to pivot within the plastic bearings as I move the rear rings, and then re-tighten for the next group.