Then why not go to the Weatherby .300mag or one of the other high folutin mags.
I've had 3 of them (.300 Weatherbys), down to one right now. One actually got rebarrelled to .300 Win and it shoots one heck of a lot better without the pre-eroded throat. The other is a bit of an embarrassment because my Winnies are outrunning it with smaller charges of the same powder. And not by a little.
Then again why play with a 180 when a 338 will handle 250gns?
Actually it will handle 275 grain A-Frames rather nicely, at least my 7 pound Kimber in .338 Win Mag does. Then there's the 300 grain SMKs I throw around in the Edge. They are rather gratifying when the wind kicks up.A better question would be, why would you shoot 180, 210 or .225s in a .338 when the .30 calibers handle that range of bullets?
Then again why play with a 338 when a 375 will handle 300gns.
See where this goes.
Actually, it goes to at least 350 grains but commonly, sure 270-300 grains is about right. I've got 2 .375s, it took me 14 months to shoot out the barrel on the first one. That's a pretty good trick, you should try it sometime. Invigorateing, with just the right touch of cavalier bravado. It's a very good training aid for guns that are actually big.

My .375s kick considerably less than my current .338, and to me noticeably less than one of standard weight. That leads to the question of why use a .338 when the .375 will kick you less and be legal for everything, no matter how big? (I'll answer that myself, since I already wrestled with it. Less weight.)
A 30-06 is the best average round for the avergae guy.