I hit a buck with a 100gr. TTSX this year at about 50yds with my .257 Weatherby (Too much power, too close of a shot for that gun, all that, I know). It would have impacted in the low 3000s, and I knew I might have some close shots, as well as long shots which is why I chose the TTSX.
The deer was walking across in front of me stopping and eating every few steps. He stopped right in front of me and I pulled the trigger. The deer didn't flinch, did not react in any way. He started walking along the same path he was following. I reloaded, half flustered because I couldn't understand how I had missed such an easy shot, but considered a distinct possibility as the deer hadn't reacted. I took another shot and the deer fell over there.
The first shot went right through the deers heart, he was dead on his feet and didn't even know it. The second one hit him in the lungs and planted him right there. In the 10 yards he walked there wasn't a spot of blood. When we skinned the deer there was no exit damage anywhere on the deer. The heart shot on the other hand left the deer bloodshot from the edge of the front shoulder to 2/3rds of the way to the back leg.
I would think that this result is pretty much the best that can be expected at such a close range with such a fast bullet. The shots were clean though, no massive exit wounds, which means that it stayed together as it should. I found it interesting that the blood shot was all on the entry side, but there wasnt much actual meat lost. If it would have been a shot in to meat it would have wasted the deer. If it would have been a bullet that doesn't hold together as well (ballistic tip, silver tip) it would have made a mess of the deer.
As I've only shot one animal with these so far its not much of a sample, but what really stood out was the lack of blood trail, that would be my only complaint.