My example is that I own an iron sighted target rifle in .308 Winchester with a Kreiger barrel on a Wichita action.
I have pretty good medium range loads that shoot okay to about 800 meters.
The same loads are pretty much sub-sonic at slightly beyond 1000 meters and accuracy is terrrible with many impacts well below the target and dispersed left or right with no consistancy. This was not so obvious at Homestead (900 meters) maybe due to the higher mountain elevation gave this marginal load, artificial ballistic help of sorts.
I now have hotter handloads specifically for this longer distance task, for more common use at lower elevations.
My next task will be experimenting with Varget powder. I hear it's an optimum powder for 308 handloads.
In my case, I want the need for speed/accuracy purely to stay supersonic at 1000 meters or thereabouts on paper targets.
ymmv

If you consider most benchrest loadings, the most accurate seem to generally be at the very top end of the pressure curve (hottest).
Brass life etc are not even considered by these folks, as it is all about accuracy.
In handgun, however, the higher pressure loadings MAY do well out of a machine rest, but poorly when a human operator is involved.
Increased recoil, noise, muzzle flash etc all have a very negative impact.
You may have a smoking hot - Uber accurate load, but will never shoot it to potential due to operator shortcomings.![]()
I'm from the school of full speed ahead. In modern centerfire rifles they are designed for it and from my experience always shoot better with 100% density full loaded case.



























