They have a thicker case which can be hard on your ejector, but otherwise... yes.
As far as I know, they are close but not the same. You can use both cartridges with 7.62x51 labelled firearm but cannot safely use 7.62x51 ammo with .308 marked rifles.
Well I am not so sure about that...the Keltech RFB's are labelled 7.62 in the US but mine is marked .308. Pretty sure they are identical.