I have a smoking load in my Vanguard 300 WSM with the 165 GMX.
It chronys 3200+ and shoots under 1 moa, [Reloder 17]
BUT....I have not shot any game with it yet, so maybe this coming fall.
I think they would be best in a larger, tougher animal [Elk]
I also run the 300wsm with the same combo, shot two animals so far, first one was a double lung at 400y, pencil hole wound channel...bit of a chase but it did the job. The second one made full contact with the heart and opened the bullet up better. No chase on that one, and it was at about 550y. They are my go to bullet now...they are match accurate...or so I've found.