I thought I'd chime in as I've been reloading for just over a year, however by no stretch do I consider myself worldly in terms of experience. I've tried Frontier, AIM, Winchester, Berry's and DRG lead bullets. I have not tried Zeros. From my experience, I did not really see a difference in terms of accuracy if I kept to one powder for all bullet brands. I did however see variances in accuracy, cycling, shot acquisition whenever I switched powders (I've used Titegroup, Bullseye and HP-38). All in all, I'd always try to find a balance between economy (cost) and what is available because it is ultimately the amount of practice you put in your shooting/drills/league nights and matches that will determine if one bullet is better/more accurate than another.