Mooncoon's advice is solid. Unless you are married to the 45-60 cartridge, others will serve as well, or better. The 45-70 is certainly the default .45 cartridge, brass is easy to find, and lots of guys have dies and molds if you don't reload. (You will have to start reloading if you aren't already, if you want to do much shooting of the old calibres). I personally shoot a 45-90, Winchester 1886. In the real world, it isn't the ideal BPCR rifle. It's hard to clean, and recoil is not for sissies, but mine shoots like a champ. I looked at a few Sharpes repro's this winter, and they are pretty nice, but the American ones cost lots of coin, and there is a waiting list for a new one. I don't see a damn thing wrong with the Italian ones, Pedersoli looks pretty nice, and is half the money. I owned a Browning 78 single shot for awhile. It was a really nice rifle, but it had the same trigger problems as every other '78. There are other Hi Wall repros out there, in a variety of calibres. (I have had a love affair for years with the Winchester Hi Wall.) Back to the 45-60, as I said, if you aren't married to it, the longer cases and bigger powder charges in some of the larger calibres will give you a bit of extra oomph at longer ranges. Having said that, you can expect more recoil, especially in the likes of the 45-125. OBTW, there are a few 45's for sale on the Equipment Exchange right now, some even appear to be reasonably priced.