I use a 180-grain Accubond at 3,070 f.p.s. as my standard hunting bullet for my .300 out of my Sako. Having said this, of the two deer that I have dropped with this load, the shock damage to the animal has been pretty extensive, notwithstanding the fact that this is a bonded bullet that performs like a Partition. One of the deer was shot downward, across a ravine from 250 yards away; and the other was shot standing from about 150.
While I love the plain Hornady 180 grain Spire Point, last year I shot a large whitetail at close range (through the chest and out the far shoulder) with this bullet out of a .30-06 with a muzzle velocity of 2,640, and the damage was extensive, almost comparable to what I saw from the .300 in the cases above. I can't imagine what this bullet would do to a deer when started at over 3,000 f.p.s.
If you want a load purely for deer, as opposed to an all-around load, I agree with the posters who suggest slowing it down a bit. On the other hand, the kills I have seen from the Barnes TSX have been impressive and clean, and the wound channels have not been disproportionate. I figure that a TTSX from 165 to 180 grains, driven at full velocities, could likely produce the ultimate hunting load in the .300 Winchester Magnum, a load that is useful for all big game hunting situations one might encounter in Canada.