There is no hard and fast rule but it is quite likely there may be some change in POI, unless you have a torque driver and have pre torqued your screws and can then reassemble with the same exact torque. It is a small investment if you find you feel the need to disassemble your rifle during a hunt. I personally would never do this during a hunt, a good cleaning and rust preventaive coating prior to the hunt and then again after if necessary, but never during. One of the reasons I like stainless/synthetic for my working rifles. My 375 H&H is stainless but in wood and mounts are blued, Even after 16 days in the Congo with rain every day and 100% humidity and 30 deg weather, I had some light rust on the mounts but certainly nothing that didn't come off with a toothbrush and some WD 40. I did remove my bolt during the hunt and wipe it down and oil it a bit as 700 bolts are not stainless and are prone to rust if not taken care of.