I have shot wolves with a 22lr, 6mm, 7-08, 308 and 338. The 22 was to finish ones I had trapped and was a 10 foot shot to the noggin.
The one I tagged with the 6mm was in a pack of 6-8. It was a 300 yard shot with the wolf sittin, facing me, in mid howl. I believe I hit it in the chest with my 100gr deer load. When I hit it the rest of the rest of the pack went bezerk, howling and yipping. It was just before dark so I left it to the next morning. I found a very good blood trail that disappeared in 100 yards, never did find it.
The 7-08 was on a wolf that ran at me while pushing bush for deer. It realized I was not a deer at 20 feet and wheeled around and stopped to look back at me at 40-50 feet. I chest shot it, facing me and it dropped right there but it did hop and flop around for close to a minute, I found the 140 grain accubond just under the hide of the far rear leg.
308 and 338 were longer shots but put them down within 50 yards and were what I was carrying while moose/deer hunting. I just skin mine for the fur auction for trim. None of the hides were ruined by the shot and the hole was easily sewn up.
If I was targetting wolves I would take the 300wsm or my 25-06 as both shoot accurately at long range. I wouldn't worry about clip capacity or having special guns for close work because there not going to attack you, if they are that close you probably won't even know they are there.