Let me offer a suggestion that works well for me, and that's a chamber check. .45 ACP headspaces on the case mouth, so you want an OAL that allows that to happen (you can go fractionally too long, but it's not a good idea and can create reliability problems).
Remove the barrel from the gun. Take an empty cartridge case and resize it. Drop the case into the chamber. Without a bullet it will drop easily into the chamber and stop when the case mouth contacts the end of the chamber; in other words, headspacing exactly as intended. Note where the rim (back) of the case lines up with the hood of the chamber (the projecting shelf that sticks out from the end). The end of the case and the hood will be almost even; usually the case is slightly inside the end of the hood.
Now do the same thing with one of your rounds. Drop it into the chamber of the barrel.
If it doesn't drop easily into the chamber, you need to check and adjust your crimp. As stated, it just needs to be a taper crimp that simply straightens the case walls out (when the bullet is seated, there will be a slight bulge in the case around the bullet, which is what holds in in place). Too little crimp and the cartridge can't drop inside the chamber easily; and overcrimping can cause the brass case to bulge below the crimp as a reaction, creating the same problem.
If the cartridge projects too far out of the chamber (i.e. past the hood) you also have problems. I'm betting you see that your cartridge is sticking well beyond what the empty case did. Not only will the gun not always fire in this situation (it's designed not to), but you will also be risking high pressures if it does fire. The slide can force the bullet into the rifling grooves as it closes, pushing the bullet into the case, and allowing the gun to fire but with increased pressures.
I'm betting you find an OAL of about 1.25" works well, but a chamber check allows you to get it set precisely for your individual gun. And different bullets (230grRN vs 200grSWC vs 185grSWC, etc.) and even different brands can require different OAL.