1 an 14 twist 22-250

You can try heavier bullets in a 1-14 barrel but chances are you'll find the accuracy will suffer.

I have a 22-250 with a 1-12 and I find it only shoots 40gr and 50 gr bullets well. Anything over 55gr is a waste of money for me.
 
a 14 twist would be marginal at best with anything heavier than 55 grain. My 14 twist shot 40 grain VMAX the best, and my 12 twist liked 52bthp best
 
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