I've only fired about 150 rounds through a 10/22, but for me shooting it left handed seemed a bit more uncomfortable than it should be. What I mean by that is, first the shells somehow managed to bounce right into the collar of my shirt more than once (I was shooting leaning on a wall to my right though) and I got at least 10 stuck in the crook of my elbow. That didn't hurt as much but it makes you jump and I could see it make somebody squeeze one off accidentally. The other issue was the ejection port is so close to your face and the chamber spewed crud right into my right eye every shot. It was pretty clear it would be unsafe to fire a 10/22 left handed without safety glasses and impossible to shoot with both eyes open without eye protection.
Still, it was pretty fun with a red dot scope. It just didn't seem like it was as safe to shoot as I would like. Not worth the 300 bucks to me.