OP,
I originally had all four barrels for my Quad, but ended up selling them and getting two Lilja barrels in .22LR and .17 HMR after doing a bunch of comparison testing on paper and critters.
The .22 WMR is the better option if you're primarily going for smaller fur bearing animals (larger than groundhogs) withing 100 yards. The .17 can do it, but bullet selection and shot placement is critical. Ribs become the issue; you need to overcome them and still create a large enough wound channel for an efficient kill. The .22 WMR does that well within that distance. With the .17 HMR, you're better off doing head shots with one of the 20 gr. bullets, which is more challenging, especially if he's on the move.
For your application the .17 HMR is the better choice. It's generally more accurate, flatter shooting and bucks the wind better. It really shines on small animals up to a groundhog size. I've killed many out to 188 yards, the trick is to lung shoot them with the 17 gr. VMAX bullets. It stones them every time. If you need to take out the odd larger animal, it can be done. Just keep it within a practical distance.
Get a scope with turrets so that you can dial in your shots precisely.