No, but I can't think of a reason why not. The ballistics will be different than what the irons are set for though, won't make much difference at 100m I think. For comparison, today I shot 10 rounds of .308win / 208gr Amax / 44.8gr H414 as a load accuracy test, it wasn't as great as my normal load of .308win / 168gr Amax / 42gr 8208XBR, but only around 0.5-1 moa worse. Rifle is a 26" 12 twist.