It really will depend on the rifle ammunition combination. Enough people have posted with good accuracy results from 10-22's that I have to believe they are capable of decent accuracy, although that hasn't been my personal experience. On the other hand, most of the rimfire manufacturers have at one time or another built good quality 22's. Remington, Winchester, Mossberg, Brno, etc have all built target 22's. Most barnyard Cooeys don't qualify, though I am sure that someone will chime in with their super accurate Model 39 shortly (and I have a Model 82 that I enjoy shooting very much). A good used Rem 37 Target, Win 52, or one of the others will allow you to take advantage of all the accuracy you can wring from a 22 without the expense of the expensive European brands. You will have to test the rifle with as many brands of 22 ammo you can find, and then buy a good supply of that ammo from the same batch. Once that batch is gone, you will most likely have to test over again. I have seen some amazing shooting from 22's on occasion. Keep in mind that in some ways, it is much more difficult to be accurate at LR (comparatively) with rimfires. FWIW - dan