I shot two coyotes with a Win 9422 magnum. Both were dead on the first shot, but I put a second round in to both for insurance. One coyote was shot at 125 yards, hit him in the lungs and down he went, came right back up and shot him in the head. The other coyote was shot in the shoulder, bullet went through to the lungs and he was dead, but I put a second round right through the ribs and it destroyed the heart, shot was about 75-80 yards. Now I use either the 222 rem mag, or the 6.5 CM.