why limit yourself to only broadside <100yd shot, using the minimum caliber and or marginal bullet weight? as a big game guide i know that shot of a lifetime probably won't be the the "ethical" shot. more often than not its a running animal at least quartering away, is anyone honestly willing to pass on that "book" buck because its not standing like bambis dad waiting to die? i'm not saying blast away at any range willy nilly (yeah i said willy nilly) wounding and losing animals. but use the largest caliber you can shoot confidently and the best bullet you can afford, and truthfully with the cost of licenses, fuel time, the cost of a couple boxes of "premium" bullets (accubond, partition, corelockt, sirroco, trophy bonded) is not going to break the bank. any of the higher quality ammo in a large enough caliber will pass thru a bucks "rear end" and reach the vitals with enough energy to destroy the vitals. Lets face it's about tearing sh*t up destroy the mechanism and the machine will stop.
if you're limited to 243 (because of size, age, recoil sensitvity, injury) know that you need a 100gr bonded and can't take that buck @ 500yds running dad away, but if you can shoot your 30-378 accurately that 200gr accubond will crush the animal as far as you can see it.
shoot what you have, shoot it straight, know your limits and that of your weapon