There are other considerations against the 22-250 that have not been mentioned yet. The biggest issue with 22-250 in a high volume gopher field is heat. The barrel will heat up within 10-15 rounds.
Smaller cases like the .223 Rem can go many more rounds before the barrel overheats.
Something small like the 221 Fireball is even better cause it can be shot a lot before the barrel gets hot.
Spend any time in a gopher field in Southern Alberta and this will become painfully apparent. I started out with a 22-250 12 years ago. Then I went to a 243 to gain distance and reduce wind drift. Then, tired of constantly overheating barrels I went smaller, to a 6BR, then a .223 Rem and now a 221 Fireball.
With lightweight bullets, the 223 and 221 are not long range rifles but they blow the living crap out of gophers, are ridiculously fun to shoot and can be shot most of the day without burning the barrel. The 6BR with medium weight varmint bullets is my chouce for longer range shots.