.224 Barnes 53 gr TSX FB and the 22-250 Load Data

Bullet Weight: 53 gr Case Trim Length: 1.902" S.D. 0.151
Bullet Style: TSX FB Primer: Fed GM210M B.C. 0.204
COAL: 2.350" Barrel Length: 24"
Case: Winchester Twist Rate: 1:14"
Charge Velocity Charge Velocity Load
Powder (grains) (fps) (grains) (fps) Density (%)
 TAC 32.0 3409 36.0 3764 81
IMR 4895 33.0 3365 36.5 3769 93
Varget 34.0 3434 37.5 3805 95
AA 2520 35.5 3429 39.5 3781 90
IMR 4320 34.0 3318 37.5 3744 93
RL 15 34.5 3452 38.0 3848 96

This is from the Barnes site and it does not copy well so try this . . . http://www.barnesbullets.com/files/2015/06/22-250Remington.pdf . . . and they did not mention either of your powders but 4064 is close to 4895 and 4320.
At 3800 fps I am sure the screaming as it passes down the bore could be heard in our neighbouring provinces!
 
Loaded for three 22/250's over the years. All varmint barrels. In all three H 380 was the best with 52-53 gr bullets.
 
Code:
Cartridge          : .22-250 Rem
Bullet             : .224, 53, Barnes 'TSX' 30180
Useable Case Capaci: 39.966 grain H2O = 2.595 cm³
Cartridge O.A.L. L6: 2.350 inch = 59.69 mm
Barrel Length      : 24.0 inch = 609.6 mm

Predicted Data for Indicated Charges of the Following Powders.
Matching Maximum Pressure: 62000 psi, or 427 MPa
or a maximum loading ratio or filling of 103 %
These calculations refer to your specified settings in QuickLOAD 'Cartridge Dimensions' window.
C A U T I O N : any load listed can result in a powder charge that falls below minimum suggested
loads or exceeds maximum suggested loads as presented in current handloading manuals. Understand
that all of the listed powders can be unsuitable for the given combination of cartridge, bullet
and gun. Actual load order can vary, depending upon lot-to-lot powder and component variations.
USE ONLY FOR COMPARISON !

4 loads produced a Loading Ratio below user-defined minimum of 85%. These powders have been skipped.
Powder type          Filling/Loading Ratio  Charge    Charge   Vel. Prop.Burnt P max  P muzz  B_Time
                                      %     Grains    Gramm   fps     %       psi     psi    ms
---------------------------------  -----------------------------------------------------------------
Alliant RL17                       103.0     39.8     2.58    3820    98.8    58488   11007   0.936  ! Near Maximum !
Hodgdon CFE223                      93.5     38.4     2.49    3801    99.0    62000   10392   0.924  ! Near Maximum !
IMR 4895                            98.7     36.4     2.36    3801    98.8    62000   10484   0.931  ! Near Maximum !
IMR 3031                            99.5     34.3     2.22    3798   100.0    62000    9579   0.927  ! Near Maximum !
Ramshot BigGame                     99.0     38.8     2.52    3795    98.6    62000   10367   0.924  ! Near Maximum !
Winchester 748                      91.6     36.3     2.35    3790    99.8    62000   10002   0.925  ! Near Maximum !
Alliant RL15                        99.5     36.6     2.37    3783    98.3    62000   10378   0.931  ! Near Maximum !
Winchester 760                     103.0     40.1     2.60    3780    94.5    60712   10776   0.932  ! Near Maximum !
Hodgdon H414                       103.0     40.1     2.60    3780    94.5    60712   10776   0.932  ! Near Maximum !
Hodgdon BL-C2                       94.0     37.8     2.45    3778    99.5    62000   10221   0.934  ! Near Maximum !
Hodgdon H4895                       96.0     35.4     2.29    3775    99.1    62000   10183   0.930  ! Near Maximum !
IMR 4320                           101.4     36.8     2.38    3767    98.6    62000   10016   0.917  ! Near Maximum !
Hodgdon H380                       100.6     37.9     2.45    3752    97.1    62000   10297   0.936  ! Near Maximum !
Hodgdon H322                        92.8     33.2     2.15    3747   100.0    62000    9298   0.923  ! Near Maximum !
Alliant AR-Comp                     94.6     33.7     2.18    3744   100.0    62000    8861   0.930  ! Near Maximum !
Hodgdon H335                        87.4     35.1     2.28    3741   100.0    62000    9502   0.929  ! Near Maximum !
IMR 8208xbr                         94.7     34.9     2.26    3736    99.5    62000    9708   0.927  ! Near Maximum !
Hodgdon Varget                     102.0     36.3     2.35    3733    98.1    62000    9931   0.923  ! Near Maximum !
IMR 4064                           102.7     35.8     2.32    3730    98.3    62000    9823   0.927  ! Near Maximum !
Ramshot TAC                         94.0     37.3     2.42    3714    96.5    62000    9994   0.931  ! Near Maximum !
Ramshot X-Terminator                91.8     36.1     2.34    3703    98.6    62000    9662   0.932  ! Near Maximum !
Alliant RL10x                       90.4     31.4     2.04    3701   100.0    62000    8790   0.936  ! Near Maximum !
IMR 4007ssc                        102.0     38.1     2.47    3694    93.9    62000   10000   0.937  ! Near Maximum !
Hodgdon Benchmark                   93.9     34.1     2.21    3691    99.7    62000    9282   0.928  ! Near Maximum !
Alliant RL7                         85.2     30.4     1.97    3642   100.0    62000    8306   0.935  ! Near Maximum !
Ramshot Hunter                     103.0     39.2     2.54    3560    92.5    50115   10206   1.012
IMR 4350                           103.0     37.7     2.45    3508    91.0    51603    9529   1.005
 
IMR 4064 load for my 22-250 ran 35.7gr, with 40 thou jump using 53gr TSX and using cci 250 mag primers. This is a hot load so work up and find your sweet spot. Varget would be another great choice.
 
Thanks for the info gentlemen. Probably trying to find a pound of Varget would be the best solution...but I have 8# jugs of both 4064 and 4350. I will use this coming winter to put a load together.
 
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