In my Ruger #1S [1:14" twist], I've found Hornady 45 gr. Hornet (0.223") & Sierra 40 or 45 gr. Hornet (0.224") bullets are both fantastic, [sub-MOA] notwithstanding the Hornady are 0.223", vs. 0.224" like the barrel's groove diameter.
I snagged 1k of Speer's 46 gr. RNFP to try this summer to see if they can match, or exceed my results to date.
Not much difference, accuracy wise, between H110, W296 & Lil Gun. All of them were far better than W680, except for a fluke group now & then that I could not repeat. I saw no need to try 2400.
Based on a fair bit of testing, I now use only SPP [my best results were with S&B SP; tried CCI SP, CCI SPM, CCI SR, FSP & FSR but they did not compare with my results with S&B SP], which are still relatively available & affordable.
After fooling around with R-P, WIN, PPU [which I now use solely for cast bullet loads because of their lesser case capacity], I've settled on Hornady brass.
Depending on your barrel's twist rate, you may find that it does not like the longer pointy bullets, like the V-Max's, Barnes, Nosler, &c. Plus, the Hornet denoted bullets will expand at the lower velocities attainable from the Hornet case.
Try a couple of different seating depths. My rifle MUCH preferred the Sierra 40 gr Hornet at a C.O.A.L. of 1.684" [0.202" seating depth] vs. 1.720" [0.166" seating depth as the Sierra manual suggested], while the Hornady MUCH preferred being at a COAL of 1.790" [0.223" seating depth] vs. 1.764" [0.249" seating depth] or 1.750" as suggested in the Hornady manual. Go figure!
Also, remember that a 1 gr. change in powder charge is a HECK of a lot in a case with but ~12.0 grs. of H2O in usable case capacity.
Finally, be mindful of your case necks. I managed to bugger up a number of them by not paying attention when I was sizing the brass & the expander button mashed the case necks. [Keep your shell-holder clean; it turned out that there was case lube built up on one side of the shell-holder which cocked my cases off to one side]
Hope this helps.
