For me, a 22 handgun is a plinker or a cheap practice gun for a centerfire piece. If your purpose is plinking only, I'd suggest a Ruger MkII or III. If purpose is practice for a full-bore pistol...pls read on.
I had a Ruger MkII and a Browning Buckmark back when I had several 1911s. I sold the MkII first, because it didn't feel anywhere close to my 1911s. Later sold the Buckmark together with my last 1911. If you are a semi-auto shooter, try to find a .22 LR version of your semi-auto centerfire of choice.
The Browning Buckmark has similar ergonomics/controls to the 1911, for example. Since I mainly shoot .357/38 revolvers these days, I kept only the S&W 17-2 as my .22 practice revolver as it has the same format as my L-frames, although it is smaller because it is a K-frame.