Out to 300 yards is referred to as 'point blank' range by the benchrest clique. And for good reason - out to that distance, drop is nearly irrelevant. You'll notice that the preferred cartridge and bullet to this range is usually the very very mild 6ppc with lightweight flat-base bullets. Benchresters have access to streamlined boattail bullets and higher intensity cartridges, yet they prefer to go with the slower cartridges, less efficient flat-base bullets and usually shorter barrels. Simply because there's no real difference out to 300 yards - in fact the opposite is true, to a small degree.
The lesson learned here - don't worry about the velocity loss of your Magnum cartridge out to 300 yards. Yes, there certainly IS a difference on paper, and on your chrony's readout. But that difference is utterly insignificant at this range. It is WELL witin the margin of error.
It will be louder and with more muzzle flash, but all magnums will be loud with a lot of flash anyway. Hell, all guns are loud, period.