As I mentioned in the title it's a battle against these 2 calibers only. If you want to talk about your creedmor or any other caliber please start a new thread. So I'm thinking about buying a 243 or a 25-06. I reload so ammo cost isn't a problem. There is a lot more powder burning in the 25-06 so barrel life will be shorter than the 243 but you drive that 100gr bullet about 400 fps faster around 3500-3600 fps... On another note you have a wider choice of bullets for the 243. So lots of pro for each caliber... I'd be hunting anything between ground hogs to deer from 100-500 yds but would keep deer under 300 yds. Thx