Everyone is saying "Yes", and I agree. Everyone is saying "but be careful and don't ask it for more than it can do", and I agree.
You say you have better tools for the job, but want to use the less appropriate tool because you like it. I think, if you have more bullet weight available, you should use it for moose. If you had nothing else to work with, then you would be fine with the .25 if you can live within the "limitations" everyone is trying to remind you are prudent. Nice rifles are very nice; bullets, however, actually do the job that must be done. I would use more bullet if I had it.