Absolutely. You can even get 180 grain bullets for the 270 that’ll make it technically legal for bison. As for bears, Phil shoemaker gives it the nod with 150gr noslers. It’ll out run a 25 with 110 grain bullets as well. All while being cheaper and more available.
That being said, I have all sorts of weird sh*t in my safe for no good reason so fill your boots.
I had a disheartening evening on the ballistic calculator a decade and a half ago where I realized bigger bores’ greater efficiency at turning pressure into kinetic energy largely offsets the ballistic advantages of the smaller bores at all practical hunting ranges. Out to further than most of us would ever shoot.
The same case needless to say moves more weight at more speed the bigger you go, with a practical cutoff of .375 due to ballistic coefficients after that for any hunting of reach. My pet .375 Kemano wildcat throws a 260gr Accubond with a .30-06 powder charge so as to remain supersonic at 1000 yards, and do 90% of what I’d do with a .375 H&H inside 100. Greatest thing since sliced bread, it is not, just another collection of compromises, ones I find agreeable. It almost tricked me into thinking just stay at .375 and make everything I own that bore.
The big caveat, is of course recoil, and that’s where .25s reign supreme. I say it often, even guys that could really shoot, shot better with 6mms, .25s, 6.5s, .270s and 7s. After all that playing around, I started with a favourite of 7s, slid to .270s for a good bit as they always blew me away with their outsized effectiveness and how well people shot them, and I jumped right past 6.5 and embraced .25. I like it as it’s topped out at the .270s lighter weights, 110-130 which are of course the go to .270 load in the 130gr flavour.
Then, regressing back upwards in bore I had to admit .30 is a pretty damn stellar middle ground between all I want from a bore. That’s a dead horse though, and while I’ve tried to cut down to just .30 I haven’t been able to eliminate .257 and .375 yet. In the end, we pick the compromises we find most agreeable, and all I’ve done is settle on the bores that suited what I was handloading to anyhow; downloaded .375 with mid range weights, and .270s with 110s. .30 is just a too good and irritating do all I can’t argue against.
As for Bison, I’ve loved making that case repeatedly, and it’s my favourite game meat. But I gotta recognize only a handful of us on here in the northwest hunt them, and while it’d do it I wouldn’t
choose a .270 for that job even with a load that meets the requirement. In the same breath, if it was all that was available, I’d use it without a third thought.