Despite what Ackley said about the 250 Savage AI, it's only true for the time period he did the experiments with those conversions, and if you can duplicate barrel lengths, contour, etc.
I spoke personally with Mr Ackley about the conversions he experimented with and made famous.
He readily admitted, his figures were almost always for stronger firearms than the original cartridges were designed to be used in.
With the powders available now, there is no reason the 250 Savage, when chambered in a strong rifle, such as the Ruger M77, shouldn't be able to be right on the heels of the Improved version.
The thing about most reloading info available, which I've seen, is that it stops with 100 grain bullets.
It's not until you start loading 115-120 grain bullets that the AI version shows any real improvements, and even then, if you load your original cartridge to the same pressures, there isn't enough velocity to make it worthwhile.
Now, if the OP just wants to have the conversion done, to scratch an itch, go for it, but before you do, load your original cartridges up to the same pressures created with 250SavAI, loads, so you have something more realistic to compare to.