While I admittedly base this recommendation on a very limited sample size of two deer, I would stay away from the 100 grain Nosler BT's. Both times I shot deer with that bullet @ 2900 fps out of a .257 Roberts, I was left shaking my head.
Deer #1 was a small buck taken with a running shot that landed too far back (thanks to a last minute change in direction just as I was letting off the shot) and hit the ball joint of a rear leg. Penetration was no more than 4", and what I found was the bullet jacket completely devoid of any lead, resting in the hip bone. Now, yes, the deer died from that shot from extremely rapid blood loss. And yes, it was about the heaviest bone in the deer's entire body. But now matter how you slice it, that was way, way too little penetration. A good bullet should be able to reach the vitals on a deer regardless of shooting angle.
Deer #2 was an even worse experience. Shot a medium-sized buck broadside through the lungs @ 35 yards. Entrance wound showed a good deal of trauma right under the skin -- but both lungs looked like someone had simply poked a pencil through them and exited out the far side. My guess is that the core separated/disintegrated upon impact, leaving the jacket to poke a hole through the animal. In this case, I ended up with a rather long tracking job before finally recovering the deer -- which certainly had been able to run a good ways before going down.
I know that there are a lot of people who are very happy with the BT's, but I'll never hunt with the 100 grain .25 cal bullet again. Which is a shame, because that particular rifle is a fairly indifferent shooter except with a 100 grain BT, which suddenly turns it into a 3/4 MOA rifle.
For what it's worth, I subsequently switched to a 117 grain Hornady BTSP, and found it to be an excellent performer on several deer.