Canuck525, overloading a cartridge until the pressure approaches the failure point of the rifle is nuts. Having said that my .308 is configured in such a way that I am driving a 200 gr MK 250 fps above the maximum published velocity. I can achieve this because my barrel is 28" long and my chamber is cut in such a way that the bullet does not extend into the powder capacity of the cartridge. As a result my OAL is too long for the magazine. If your .280 Remington is built to SAAMI specifications you are playing with fire, regardless of what you have got away with in the past. Perhaps you have chosen a slow twist barrel, perhaps your bore size is on the large side of 7mm, and you might have an inordinate amount of freebore. These things do help to reduce pressure. If your rifle is outside of SAAMI specifications you should of said so up front to prevent the uninitiated from attempting to match your performance. We don't care what you do yourself, but I believe that if your rifle is built to SAAMI standards your technique is reckless and should not be followed.
Todays handloaders have no excuse for recklessly running into dangerous pressure situations. If you experience a stiff bolt lift and continued to increase the powder charge, you are going to find the powder charge that causes the rifle to fail. Driving a given bullet faster is a simple matter of choosing a longer pipe chambered for a cartridge with greater powder capacity.
I don't trust dimensional changes in brass as a reliable indicator of pressure. Counting the reloads possible from Federal as opposed to Lapua brass should suggest why, never mind the differences between lot numbers. My Remington .375 Ultra brass seldom makes 6 reloads, and my loads are slightly below the book maximum, but I worked up the loads using a chronograph and when the velocity plateaued I dropped back a grain and called that my working maximum.
I am curious about your choice of Re-22. In medium capacity cartridges, slow powders often run out of capacity before a reasonable velocity can be realized, in fact it can be impossible to create an overload in some cases regardless of how long your drop tube is or how heavily compressed the load. Personally I think a compressed powder charge is an indication that the wrong powder has been chosen, but there are those who will disagree. There are some things here that don't add up.
Since you appear to be a velocity addict, you might as well build a 7mm Ultramag, a 7/.338 Lapua or a 7/.378 and be done with it.