I got to see a lot of cartridges work guiding grizzly, moose, and mountain goat hunts here in BC.
Out of all of them, the most impressive were the fast ones. Very consistently the .270, 7mm Mag, .300s produced the best results, even on the biggest grizz this country’s got. Of the fast ones, the .270s the easiest to live with for many folks. The least effective were the slow and heavy ones, ala .45-70 class. I’d put .270 near the top of the heap just below the 7mm Mag with a quality bullet, and most shoot it extremely well which is a big factor.
Been on a few wild bison hunts as well, and I’d happily use the .270 with a 150gr there, that’s the one scenario I’d load it heavy. It’s one of my favourite hunting cartridges, and I came to that through watching it work rather than any sentiments about the cartridge or .277 bore. Trust me I tried for most of 20 years not to like it, in the end I couldn’t.