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I would think that a slower powder would work better. Lots of RL-22 and recently IMR-7828 in mine. Try the Nosler reloading forums, there are a lot of 280AI shooters on there.
I load mine with 7828ssc and 168gr Berbers , I shoot mine at 2920fps . One word of caution when you get to the top end of loads this powder comes up to psi fast, I found this in mine gun anyway.
I forget what load I ended up with but I'm using IMR 7828SSC now. H4381SC seem to also do well for me. I'm shooting Barnes TTSX 150 gr. I've got IMR 4350; shoot it in my 30-06 but reports pointed to the 7828 and 4831 being superior for this caliber. I might try the 4350 for kicks and see what it produces.