Here is a cool, cheap way to test your preferences and find out if you should be spending more money on a permanent set. I've seen the permanent sets at a gun show but I can't for the life of me remember the name of the company, and the internet is no help. They may have gone broke, since as Aqualung suggests, it's not for everyone.
Take out the space when you copy and paste:
http://www .nitesiters.com/Nitesiters_Handgun_Night_Sights.html
Stick on photo luminescent dots! Multiple colors, etc.
Or you can just try carefully painting on some dots with bright yellow nail polish (comes off with acetone and will leave your black sights black again). Clean your sights with acetone first, try a small spot to make sure the finish stays on. I haven't heard of factory sight finish coming off with acetone, but some used guns with repainted sights might surprise you.
I have done various things to my revolvers and find that highlighting a square portion of the front sight, at point of aim for my favorite ammo and distance, is the most useful thing to do for me, since the front sight is what I need to focus on. There are plenty of shooters who love their three dot revolver sights though, and it's especially appealing if that's how you operate your auto loaders.
Let us know what you learn!