I have always owned at least one 30-06, and at times, up to 4. The amount of game I have shot with the 30-06 would fill a fill a large moving Van. It has always been dependable and up to any task I put it to, including big bear. [Grizz] I have been a Partition "slut" for about 4 decades, but have always experimented with other designs to get an idea of how they perform on game. The 30-06 with the 180 grain bullet makes for velocities that do not commonly cause bullets to come apart. Even most 165 grain designs will stand up at '06 Velocities. When you drop down to 150 grain projectiles, the scene changes. At 3100 fps, some 150 grain designs are too fragile to trust, and at this weight a better bullet is a good idea. If I shoot 150's [seldom], I opt for the Partition or some bonded bullet that shoots well. At 165 grains, I still prefer a good bullet like the Partition, but there are many bullets that work well in this weight. In 180 grains, the Hornady, Speer or Sierra designs are fine for most non-dangerous game, but if you are thinking of chasing big bruins with your '06, then a premium bullet is still the best choice. My personal preference for this application [big bears] is the 200 Partition at 2650 or so. Penetrates very well, and is accurate in most '06 rifles I have tried them in. The Ballistic Tips in the heavier weights work Ok on lighter game , but from 150 grains down, my personal experience has been a lot of bloodshot meat, and lousy bullet integrity. If I had to choose one bullet for everything huntable in North America, it would be a premium 180 of some sort, probably the Partition, but the Accubond, Interbond and some others would be fine, I'm sure. If your rifle shoots the Barnes TSX well, then a 165-168 grain bullet would suffice for all. I had one bad experience with the Scirocco in 180 grain out of my 30-06, so have reservations about it, but could have been a poor bullet out of the lot. Regards, Eagleye.