I am sure they will work fine, but if you are going to shoot higher speeds, you may want to look at one of the super cool new bullets
Esepcially if you expect some heavy bone...
rom left to right we have:
180gr TSX
16" penetration
179.7gr retained
180gr FS
16.25" penetration
173.2gr retained (Although a petal broke off and was with the bullet, but I lost it before I weighed it)
130gr TTSX
15.75" penetration
129.6gr retained
180gr NP
15.5" penetration
121.6gr retained
180gr Hornady Interlock
14.25" penetration
124.9 gr retained
So, we see the FS penetrated the most, with less expansion.
The Hornady proved that heavy bullets at moderate weight will still penetrate well, although the Hornady was mangled in the end, and may not have stood up at higher speeds.
The NP did what they often do when stressed- shed the front and leave the rear to penetrate deeply.
The 2 TSX bullets penetrated about the same, although the 130gr expanded larger due to higher velocity.
Here is a link to the rest of the thread, it's less abou tthe Hornady and more about TTSX bullets
http://www.canadiangunnutz.com/forum/showthread.php?t=251524