I shot a lot of stuff over the years with the 300Wby. Wolves to deer to bear to moose through mountain goats and bison with different bullets. Whether it was the 165XLC at 3370 fps, the 180 failsafe or others at 3150, or the 200 NP or A-Frame at 3050, I couldn't see the slightest bit of difference in how animals large or small died. With anything resembling decent shot placement they just tipped over.
I knew the difference, and my chronograph knew the difference, but the animals couldn't tell the difference!
Providing you select a bullet suited to the velocity (example the X bullet if using a 165 grainer at 3350+ fps) they'll work fine. On principle I think a heavier bullet is a better way to go for big game, but I put the 165'er through two big moose. And the whole idea behind a heavier bullet is increased penetration, right? But if a big moose won't stop a 165 grain premium bullet, why go with something heavier?
That's not getting hung up over a ballistics program or minutiae. In the field, where it counts, there's very little difference.
Standard 7828 is a good powder, but I did my 300Wby stuff 7-15 years ago. For 165 grain bullets, I found H4831 and RL22 the best. For 180's 7828 worked great, but so did 90 grains of H1000. With the 200 grainers, I used 7828.
This was all the old IMR stuff, the SSC wasn't on the market then. I find I've tried to simplify the last few years instead of testing every bullet on the market. If I was loading for a 300Wby today, I'd load up a 180TSX over whichever temperature insensitive powder it liked and gave me 3150 fps (H4831 Extreme, Ramshot Magnum, etc.), and call it good.
Actually, that's not quite true. I'd have a second load with the cheapest 180 grain bullet I could find (think Speer or Hornady SP), slightly reduced with H4350 or similar, for a practice load.