The Scenars are great bullets, but in my little experience with them out of my 338LAI, I do not think I would try and hunt with them.
I have had tremendous success with the 300 gr Sierra Matchking on game, despite what many say including Sierra, they really work well at distance.
I believe the Scenar is a tougher bullet and may explain why the whistled through a couple of critters I tried to make dead.
How the 250s work I can't say as all I shoot are 300 gr.